Hexamethylene diisocyanate asthma is associated with genetic polymorphisms of CD14, IL-13, and IL-4 receptor α

Hexamethylene Diisocyanate Asthma is Associated with Genetic Polymorphisms of CD14, IL-13, and IL-4RA

David I Bernstein, MD1, Grace E Kissling, PhD2, Gurgit Khurana Hershey, MD, PhD3, Berran Yucesoy, PhD4, Victor J Johnson, PhD4, André Cartier, MD5, Denyse Gautrin, PhD5, Joaquin Sastre, MD6, Louis-Philippe Boulet, MD7, Jean-Luc Malo, MD5, Santiago Quirce, MD6, Susan M Tarlo, MBBS8, Stacy Langmeyer, MS1, Michael I Luster, PhD4, and Zana L Lummus, PhD1 1University of Cincinnati College of Medicin...

V75R576 IL-4 Receptor Is Associated with Allergic Asthma and Enhanced IL-4 Receptor Function

association of the expression of il-4 and il-13 genes, il-4 and ige serum levels with allergic asthma

immune and inflammatory responses mediated by cytokines, play important roles in the pathophysiology of asthma. these responses are associated with overexpression of th2 cytokines such as il-4 and il-13. these two cytokines use common receptors for signaling that lead to identical immunological effects and regulation of the th1/th2 balance. the aim of this study was to determine whether patient...

Distinct roles for IL-13 and IL-4 via IL-13 receptor alpha1 and the type II IL-4 receptor in asthma pathogenesis.

IL-13 and IL-4 are central T helper 2 (Th2) cytokines in the immune system and potent activators of inflammatory responses and fibrosis during Th2 inflammation. Recent studies using Il13ra1(-/-) mice have demonstrated a critical role for IL-13 receptor (IL-13R) alpha1 in allergen-induced airway responses. However, these observations require further attention especially because IL-4 can induce s...

Association of TGF-beta1, CD14, IL-4, IL-4R and ADAM33 gene polymorphisms with asthma severity in children and adolescents.

OBJECTIVE To verify the association of transforming growth factor-beta1(TGF-beta1) (C-509T and T869C), CD14 (C-159T), IL-4 (C-590T), IL-4R (ILe50Val) and ADAM33 (S_2) gene polymorphisms with asthma severity in a sample of patients with mild, moderate and severe persistent atopic asthma. METHODS A clinical, laboratory, prospective study was performed in patients with persistent atopic asthma, ...